Functional proteomics aims for the elucidation of the biological function of proteins or protein groups and classes on a proteome-wide level.
This includes the characterization of enzyme activities as well as protein/protein interactions and post-translational modifications at proteins. Combining our technologies and expertise, we are able to map changes in signaling pathways as a consequence of cell-treatment or changes in environmental conditions. This can be done either by the large-scale measurement of enzymatic activities of kinase, phosphatase, protease or other protein modifying enzymes or by measurement of epigenetic modifications at proteins.
We have also developed innovative ways in evaluating and presenting complex data sets which is vital for the optimal exploitation of experimental results.
Fig. 1: Adapted from Rauh et al, Nature Comm (2013)