Over the past decade, JPT has run several successful projects for the identification of peptide hits. Among them were specific substrates for orphan proteases, kinases, phosphatases and acetyltransferases. The key to most of these screening projects was the applications of JPT's proprietary PepSpot™ or PepStar™ technologies. The respective screening libraries were designed either knowledge-based or starting from randomized sequences.
In collaboration with Bayer AG, Germany, a high content peptide library was created for screening of undisclosed targets. Overall, several million compounds were selected, synthesized and screened.