Hit to Lead Qualification
At JPT, we pay particular attention to the thorough qualification of hits. For this, hits are resynthesized, purified and characterized in multiple assays that are relevant to the target parameters/properties. Along with SAR analyses, profiling results enable a clear prioritization and selection of the most promising leads for optimization.
JPT has been engaged in several hit qualification / hit-to-lead projects, where hits for kinases, proteases, transferases, isomerases and phosphatases were transferred into qualified leads. The projects were done inhouse or during perennial collaborations with industry partners.
The hit qualification process at JPT is supported by an established network of service providers which addresses basically all properties relevant to drug discovery and other applications.