Peptide Chemistry

We have a substantial, long-standing expertise in peptide synthesis, providing tailored peptides with highest quality for even complex or unusual peptide sequences. Our highly skilled and committed scientific staff ensures that the most appropriate modifications, purities, methods, peptide synthesizers and techniques are selected for every custom peptide synthesis project.

Most of JPT's specialty peptides are provided in the highest purity (>95%), with a full range of peptide analyses including LC-MS (trap and/or quad), MALDI-MS or HPLC. A large variety of optional analyses is available e.g. AAA, NMR, CE, sterility testing, as well as peptide content determination.

The exceptional quality and reliability of our peptide synthesis service has been appreciated by customers worldwide for many years.

Selection of common peptide modifications and labeling options.

For a detailed description of the different options and a full list,
please visit our Specialty Peptide Synthesis page

Fluorescence and chromogenic labeled peptides (FITC, Carboxyfluorescein, Alexa, AMC, FRET peptides, etc.)

  • Peptide esters
  • Internally quenched peptides (FRET peptides: Abz/nitroTyr, EDANS/DABCYL, MCA/DNP labeling) guaranteed without fluorescent impurities
  • Immunogenic peptides (MAPs, palmitinylation, Pam3Cys labeling, etc.)
  • Phosphopeptides (phosphorylated tyrosine, threonine or serine) and peptidomimetics (amide bond isosteres, non-natural amino acids, etc.)
  • Post-translational modifications (PTMs) such as acetylation, methylation, phosphorylation, citrullination e.g. acetyl lysine and acetyl arginine peptides, methyl lysine and methyl arginine, citrullin, lysine succinyl, butyryl, propyl... etc.
  • Non-commercial building blocks for custom peptide synthesis
  • Biotinylated peptides (N-terminal and C-terminal biotinylation as well as biotin attached via side chains – via special optimized linker / spacer)
  • D amino acid peptides (D peptides)
  • Labeled custom peptides (stable isotope labeling (heavy peptides), chromophore, etc.)
  • Cyclic peptides (disulfide bridges, lactams, thioether-bridges, etc.)
  • Long peptides (>70 amino acids)
  • Site-directed conjugations of custom peptides with KLH, BSA, ovalbumine or other carriers

    Please inquire about additional peptide modifications not listed here

Selected References for custom peptides:

"Temporal Dynamics of the Primary Human T Cell Response to Yellow Fever Virus 17D As It Matures from an Effector- to a Memory-Type Response"
Blom et al., J. Immunol. (2013) - PMID: 23338234
"Self-Reactive Human CD4 T Cell Clones Form Unusual Immunological Synapses"
Schubert et al., J. Exp. Med.(2012) - PMID: 22312112
"The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response"
Mitrovic et al., J. Virol. (2012) - PMID: 22156533
"The Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) Influences Platelet Calcium Signaling and Function by Regulation of Orai1 Expression in Megakaryocytes"

Borst el al., Blood (2012) - PMID: 22031864
"Tim50’s Presequence Receptor Domain Is Essential for Signal Driven Transport Across The TIM23 Complex"
Schulz et al., J. Cell Biol. (2011) - PMID: 22065641
"Cytoplasmic N-Glycosyltransferase of Actinobacillus pleuropneumoniae Is an Inverting Enzyme and Recognizes the NX(S/T) Consensus Sequence"
Schwarz et al., J. Biol. Chem. (2011) - PMID: 21852240
"Chemokine Nitration Prevents Intratumoral Infiltration of Antigen-Specific T cells"

Molon et al., J. Exp. Med. (2011) - PMID: 21930770
"Functional Gap Junctions Accumulate at the Immunological Synapse and Contribute to T Cell Activation"
Mendoza-Naranjo et al., J. Immunol. (2011) - PMID: 21844382
"The Immunodominant CD8 T Cell Response to the Human Cytomegalovirus Tegument Phosphoprotein pp65495–503 Epitope Critically Depends on CD4 T Cell Help in Vaccinated HLA-A*0201 Transgenic Mice"
Reiser et al., J. Immunol. (2011) - PMID: 21810614
"Processing of HEBP1 by Cathepsin D Gives Rise to F2L, the Agonist of Formyl Peptide Receptor 3"
Devosse et al., J. Immunol. (2011) - PMID: 21709160

More references

Peptide Chemistry

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Contact: Tanja Kaan
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