Medicinal Chemistry

JPT’s Medicinal Chemistry unit has long standing experience from discovery to preclinical development projects. The team members have been critically involved in several peptide and small molecule hit-to-lead qualification and peptide optimization projects.
Medicinal Chemistry at JPT is supported by an extraordinarily high capacity in peptide chemistry, automated synthesis, analytics and purification. By using solid as well as solution phase chemistry, JPT is able to synthesize as many as 50 000 crude and several hundred purified peptides per week.
JPT is in possession of an extensive collection of building blocks and routinely does many types of peptide modifications and conjugations. Besides that, JPT has collected a significant know-how in conformational stabilization and size reduction of peptides, which is used to optimize compounds to finally meet the predefined target product profile.

Selected References for Medicinal Chemistry

"Novel Small Molecule Bradykinin B1 Receptor Antagonists. Part 3: Hydroxyurea Derivatives"
Schnatbaum et al., Bioorg. Med. Chem. Lett. (2010) - PMID: 20036120
"Novel Small Molecule Bradykinin B1 Receptor Antagonists. Part 2: 5-Membered Diaminoheterocycles"
Zischinsky, Schnatbaum et al., Bioorg. Med. Chem. Lett. (2010) - PMID: 20015651
"Novel Small Molecule Bradykinin B1 Receptor Antagonists. Part 1: Benzamides and Semicarbazides"
Schaudt, Schnatbaum et al., Bioorg. Med. Chem. Lett. (2010) - PMID: 20015645
"Small Molecule Bradykinin B2 Receptor Modulators"
Gibson, Schnatbaum et al., WO 2010/031589 (2010)
"TFPI Inhibitors and Methods of Use"
Dockal, Reimer et al., WO 2010/071894 (2010)
"Small Molecule Antagonists of the Bradykinin B1 Receptor"
Locardi, Reimer et al., WO002009036996 (2009)
"Peptide Arrays for Enzyme Profiling"
Thiele, Zerweck et al., Methods Mol. Biol. (2009) - PMID: 19649588
"Design and Synthesis of a New Class of Selective Integrin Alpha5beta1 Antagonists"
Stragies, Reimer et al. J. Med. Chem. 50 (2007) - PMID: 17616113
"Novel Small Molecule Bradykinin B2 Receptor Antagonists"
Gibson, Schnatbaum et al., J. Med. Chem. (2009) - PMID:  19552431
"Peptidomimetic C5a Receptor Antagonists with Hydrophobic Substitutions at the C-terminus: Increased Receptor Specificity and in vivo Activity"
Schnatbaum et al., Bioorg. Med. Chem. Lett. (2006) - PMID: 16876401
"8-Oxy-Quinoline Derivatives as Bradykinin B2 Receptor Modulators"
Gibson, Schnatbaum et al., WO08116620 (2008)
"C5A Receptor Antagonists"
Schnatbaum et al., WO06074964 (2006)
"C5A Receptor Antagonists"
Schnatbaum et al., WO05010030 (2005)

More references

Partner with us

Contact: Tanja Kaan
T: +49-30-6392-7878
X: +49-30-6392-7888
E: peptide@jpt.com

Quality Assurance

All production is performed according to ISO 9001:2015 standards

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