JPT provides a multitude of innovative research tools to the proteomics community. Besides high-throughput chemical and analytical approaches to accelerate discovery of novel biomarkers from biological samples, JPT developed a new mass spectrometry-based peptide standard technique for absolute quantification of target proteins in clinical and targeted proteomics. Furthermore, JPT has a decade-long track record providing services and project expertise in the area of functional proteomics ranging from elucidation of protein-protein interactions and enzymatic activities to epigenetic regulation.
|Mass Spectrometry-Based Proteomics||Functional Proteomics|
- Target discovery and validation: we evaluate the effect of your target protein in biological networks
- Biomarker discovery: we quantify hundreds of proteins, e.g. tumor associated antigens from patient blood samples in one experiment, and correlate the quantities and post-translational modification status with clinical data
- Clinical monitoring: monitoring the effect of therapeutic intervention and disease status is vital to understand and describe the effects of applied drugs on target proteins; especially the parallel quantification of large numbers of relevant proteins will facilitate personalized medicine approaches, patient stratification and companion diagnostic development
- Proteome wide quantification of proteins and protein modification states
- Proteome wide characterization of enzymatic activities or enzyme families
- Proprietary high throughput peptide technologies for highly multiplexed identification of proteins
- Unique approach for absolute and multiplexed quantification of proteins
- Coverage of post-translational modifications
- Rapid access to hundreds of thousands of peptides overing the entire human proteome
"Prosit: Proteome-wide Prediction of Peptide Tandem Mass Spectra by Deep Learning"
Gessulat et al, Nature Methods (2019)
"Development of Targeted Mass Spectrometry-Based Approaches for Quantitation of Proteins Enriched in the Postsynaptic Density (PSD)"
Wilson et al, Proteomes (2019)
"A Deep Proteome and Transcriptome Abundance Atlas of 29 Healthy Human Tissues"
Wang et al, Molecular Systems Biology (2019)
"Mining the Human Tissue Proteome for Protein Citrullination"
Lee et al, Molecular & Cellular Proteomics (2018)
"ProteomeTools: Systematic Characterization of 21 Post-Translational Protein Modifications by LC-MS/MS Using Synthetic Peptides"
Zolg et al, Molecular & Cellular Proteomics (2018)
"Analysis of Histone Modifications by Mass Spectrometry"
Völker‐Albert et al, Current Protocols in Protein Science (2018)
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Contact: Tanja Kaan