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Proteomics

JPT provides a multitude of innovative research tools to the proteomics community. Besides high-throughput chemical and analytical approaches to accelerate discovery of novel biomarkers from biological samples, JPT developed a new mass spectrometry-based peptide standard technique for absolute quantification of target proteins in clinical and targeted proteomics. Furthermore, JPT has a decade-long track record providing services and project expertise in the area of functional proteomics ranging from elucidation of protein-protein interactions and enzymatic activities to epigenetic regulation. 

Applications in Proteomics:

  • Target discovery and validation: we evaluate the effect of your target protein in biological networks
  • Biomarker discovery: we quantify hundreds of proteins, e.g. tumor associated antigens from patient blood samples in one experiment, and correlate the quantities and post-translational modification status with clinical data
  • Clinical monitoring: monitoring the effect of therapeutic intervention and disease status is vital to understand and describe the effects of applied drugs on target proteins; especially the parallel quantification of large numbers of relevant proteins will facilitate personalized medicine approaches, patient stratification and companion diagnostic development
  • Proteome wide quantification of proteins and protein modification states
  • Proteome wide characterization of enzymatic activities or enzyme families

Benefits

  • Proprietary high throughput peptide technologies for highly multiplexed identification of proteins 
  • Unique approach for absolute and multiplexed quantification of proteins
  • Coverage of post-translational modifications
  • Rapid access to hundreds of thousands of peptides overing the entire human proteome

Selected References for Proteomics

"Building ProteomeTools Based on a Complete Synthetic Human Proteome"
Zolg et al., Nature Methods (2017)
"Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome"
Kusebauch et al., Cell (2016)
"Nuclear PKC-e Facilitates Rapid Transcriptional Responses in Human Memory CD4+ T Cells Through p65 and H2B Phosphorylation"
Hardy et al., J Cell Sci. (2016)
"Histone H2A and H4 N-Terminal Tails are Positioned by the MEP50 WD Repeat Protein for Efficient Methylation by the PRMT5 Arginine Methyltransferase"
Burgos et al., J Biol Chem. (2015)
"Mass-Spectrometry-Based Draft of the Human Proteome"
Wilhelm et al., Nature (2014)
"High-Throughput Generation of Selected Reaction Monitoring Assays for Proteins and Proteomes"
Picotti et al., Nature Methods (2009)

More references

Partner with us

Contact: Tanja Kaan
T: +49-30-6392-7878
X: +49-30-6392-7888
E: peptide@jpt.com

Quality Assurance

All production is performed according to ISO 9001:2015 standards

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