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Proteomics

JPT provides a multitude of innovative research tools to the proteomics community. Besides high-throughput chemical and analytical approaches to accelerate discovery of novel biomarkers from biological samples, JPT developed a new mass spectrometry-based peptide standard technique for absolute quantification of target proteins in clinical and targeted proteomics. Furthermore, JPT has a decade-long track record providing services and project expertise in the area of functional proteomics ranging from elucidation of protein-protein interactions and enzymatic activities to epigenetic regulation. 

Applications in Proteomics:

  • Target discovery and validation: we evaluate the effect of your target protein in biological networks
  • Biomarker discovery: we quantify hundreds of proteins, e.g. tumor associated antigens from patient blood samples in one experiment, and correlate the quantities and post-translational modification status with clinical data
  • Clinical monitoring: monitoring the effect of therapeutic intervention and disease status is vital to understand and describe the effects of applied drugs on target proteins; especially the parallel quantification of large numbers of relevant proteins will facilitate personalized medicine approaches, patient stratification and companion diagnostic development
  • Proteome wide quantification of proteins and protein modification states
  • Proteome wide characterization of enzymatic activities or enzyme families

Benefits

  • Proprietary high throughput peptide technologies for highly multiplexed identification of proteins 
  • Unique approach for absolute and multiplexed quantification of proteins
  • Coverage of post-translational modifications
  • Rapid access to hundreds of thousands of peptides overing the entire human proteome

Selected References for Proteomics

“Layers of Regulation on Cell-cycle Gene Expression in the Budding Yeast Saccharomyces cerevisiae”
Kelliher et al., Molecular biology of the cell (2018) - PMID: 30207828
"Using Stepwise Pharmacogenomics and Proteomics to Predict Hepatitis C Treatment Response in Difficult to Treat Patient Populations”
Naggie et al., PROTEOMICS – Clinical Applications (2018) - PMID: 30058111
“Stereocilia-staircase Spacing Is Influenced By Myosin III Motors and Their Cargos Espin-1 and Espin-like”
Ebrahim et al., nature communications (2018) - PMID: 26926603
“A crude-MS Strategy for in-depth Proteome Analysis of the Methane-oxidizing Methylocystis sp. strain SC2”
Hakobyan et al., J. Proteome Res (2018) - PMID: 30019905
“Biochemical Characterization of Human Tissue kallikrein 15 and Examination of its Potential Role in Cancer”
Filippou et al., Clinical Biochemistry (2018) - PMID: 29928903
“Expression Profile of Human Tissue kallikrein 15 Provides Preliminary Insights Into its Roles in the Prostate and Testis”
Filippou et al., Clinical Biochemistry (2018) - PMID: 29958881
“CHESS: a New Human Gene Catalog Curated from Thousands of Large-scale RNA Sequencing Experiments Reveals Extensive Transcriptional Noise”
Mihaela Pertea et al., Genome Biology (2018) - PMID: 30486838
"Discovery and Quantification of Non-human Proteins in Human Milk”
Jing Zhu et al., J. Proteome Res. (2018) - PMID: 30489082
“Multiplex Assay for Quantification of Acute Phase Proteins and Immunoglobulin A in Dried Blood Spots”
V Vidova et al., J Proteome Res. (2018) - PMID: 30408962
“Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking”
JR Wiśniewski et al., Journal of Proteome Research (2018) - PMID: 30336047
“Dysregulation of Mucosal Membrane Transporters and Drug Metabolizing Enzymes in Ulcerative Colitis”
Erdmann et al., Journal of Pharmaceutical Sciences (2018) - PMID: 30267783

More references

Partner with us

Contact: Tanja Kaan
T: +49-30-6392-7878
X: +49-30-6392-7888
E: peptide@jpt.com

Quality Assurance

All production is performed according to ISO 9001:2015 standards

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