Immunotherapy & Vaccine Development as Contract Research

• Epitope discovery: JPT offers its technologies and expertise in discovery projects targeting specific B- and T-cell epitopes that can be used as markers for early diagnosis and progression of diseases as well as patient stratification. For the first time, high-throughput proteome spanning screening can be combined with high resolution epitope based profiling.
• Development of immune monitoring tools: JPT applies its patented approaches and know-how to develop peptide based immune monitoring tools targeting specific antigens or antigen families. The combination of technological and bioinformatic know-how with profound expertise in assay development provides efficient access to epitope resolved profiling for cellular and humoral immune responses.
• Assay development & sample profiling: JPT’s experienced scientists will work with you to develop the optimal screening strategy for your project. Seroprofiling assays and T cell assays are performed in JPT’s S2 laboratories using automatic incubation stations and trained staff assuring performance of robust and reproducible results. 

• Broad peptide technology portfolio for all development phases of immunotherapies and vaccines • Peptide platforms covering cellular and humoral immunity
• Ultra-high content peptide library concepts for deep epitope and target discovery
• GxP peptides for clinical applications
• Chemical synthesis addresses sequence diversity and post-translational modifications
• State of the art infrastructure allowing organic chemistry, sensitive production workflows (cleanroom) and assays including usage of infectious patient materials (S2 laboratories)
• Comprehensive bioinformatics for peptide selection and design

"A Vaccine Based on Recombinant Modified Vaccinia Ankara Containing the Nucleoprotein from Lassa Virus Protects Against Disease Progression in a Guinea Pig Model"
Kennedy et al, Vaccine (2019)
"Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients"
Baraniak et al, Journal of Infectious Disease (2019)
"Mass Spectrometry Driven Exploration Reveals Nuances of Neoepitope-Driven Tumor Rejection"
Ebrahimi-Nik et al, JCI Insight (2019)
"New Epitopes in Ovalbuminprovide Insights For Cancer Neoepitopes"
Karandikar et al, Immunology (2019)
"Therapy-Induced MHC I Ligands Shape Neo-Antitumor CD8 T Cell Responses during Oncolytic Virus-Based Cancer Immunotherapy"
Murphy et al, Journal of Proteome Research (2019)
"Natural T Cell Autoreactivity to Melanoma Antigens: Clonally Expanded Melanoma-Antigen Specific CD8 + Memory T Cells Can be Detected in Healthy Humans"
Przybyla et al, Cancer Immunology, Immunotherapy (2019)
"Characterization of the Immune Response Elicited by the Vaccinia Virus L3 Protein Delivered as Naked DNA"
Ramírez et al, Vaccine (2018)
"Epstein-Barr Virus (EBV)-derived BARF1 Encodes CD4-and CD8-restricted Epitopes as Targets for T-cell Immunotherapy"
Kalra et al, Cytotherapy (2018)
"PRAME Peptide‐Specific CD8+ T Cells Represent the Predominant Response Against Leukemia‐Associated Antigens (LAAs) in Healthy Individuals"
Matko et al, European Journal of Immunology (2018)
"Coordinated Responses to Individual Tumor Antigens by IgG Antibody and CD8+ T cells Following Cancer Vaccination"
Hulett et al, Journal for ImmunoTherapy of Cancer (2018)

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