CMV pp65 (495-503) - HLA-A*02:01 (NLVPMVATV)

The CMV pp65 495-503 peptide (NLVPMVATV) is one of the most widely studied epitopes derived from the human cytomegalovirus (HCMV) pp65 protein. Recognized for its strong immunogenicity, this sequence is frequently used to monitor CMV-specific CD8+ T cell responses, particularly in HLA-A*02:01-positive donors.

Due to its consistent ability to elicit robust T cell activation, CMV pp65 495-503 has become a standard reference peptide in immune monitoring workflows. It is commonly applied in transplant immunology, vaccine research, and studies investigating antiviral immunity, where precise detection of antigen-specific responses is critical.

The Human Cytomegalovirus (HCMV) 65 kDa phosphoprotein (pp65) Peptide is a high quality epitope peptide for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxicity or proliferation assays. The 65 kDa phosphoprotein (pp65) Peptide, H-NLVPMVATV-OH (Uniprot: P06725 aa: 495-503) from JPT is produced under strict quality control and quality management.

CMV pp65 (495-503) - HLA-A*02:01 (NLVPMVATV) - Specifications

• Peptide sequence: H-NLVPMVATV-OH
• Amount: 1 mg
• Purity: Trial Grade: each peptide purified to > 90% (HPLC/MS)
• Delivery Format: Freeze-dried in plastic vial
• CAS: 153045-21-7
• Application(s): T-cell immunity
• Condition(s)/Topic(s): Control, Infectious mononucleosis, Opportunistic infections, Cytomegalovirus disease
• Standard Delivery Time: approx. 10 days

Visit our webpage for more information on Peptide Tools to Study CMV

Is this peptide right for your research?

This peptide is typically used when a robust and well-characterized CMV-specific readout is required in HLA-A*02:01-restricted systems. The NLVPMVATV epitope shows high-frequency recognition in CMV-seropositive donors and is therefore often selected for assay benchmarking, longitudinal monitoring, or cross-study comparability.

It is less suitable if your experimental design depends on subdominant epitopes, broader antigen coverage, or non-A*02:01 HLA contexts. In those cases, alternative pp65-derived sequences or peptide pools may provide more informative or representative responses.

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