Alpha - B.1.1.7

WHO Designation
Variant of Concern 202012/01, abbreviated VOC-202012/01 (also known as 20I/501Y.V1)

Alternative names
Lineage B.1.1.7, UK variant, British variant, Kent variant, Alpha

First publication
Chand et al, Public Health England (December 2020)

Reference sequences given in literature
EPI_ISL_601443
EPI_ISL_581117

Sequence used for library generation
EPI_ISL_601443 (Gisaid accession ID)

JPT’s products
PepMix™ SARS-CoV-2 (S-RBD B.1.1.7 / Alpha) : Spike receptor binding domain

Mutations
H0069-; V0070-; Y0144-; N0501Y; A0570D; D0614G; P0681H; T0716I; S0982A; D1118H
These mutations characterize approx. 86.8 % of all sequences in the B.1.1.7 lineage.

Variants pertaining to Alpha may include these additional mutations:
L0005F, V0006A, S0012F, L0018F, T0020I, R0021T, T0022I, H0049Y, A0067S, A0067V, S0071F, T0076I, P0082L, S0094F, T0095I, E0096D, S0098F, R0102I, D0138H, V0143F, H0146Q, S0151G, W0152R, L0176F, E0180G, R0214L, D0215Y, L0216F, S0221L, A0222V, H0245Y, S0255F, G0261A, A0262-, D0287G, V0289I, T0299I, T0307I, V0308L, T0323I, N0354D, N0394Y, A0475V, E0484K, S0494P, T0572I, A0575S, E0583D, V0622F, A0623S, A0626T, S0640F, Q0675H, Q0677H, T0678I, S0680F, P0681R, A0688V, A0701V, A0706V, T0732I, M0740V, R0765C, P0812S, I0818V, A0831V, K0835R, A0879V, A0892V, I0909V, L0938F, S0939F, G0946V, A1020V, V1129I, E1188D, K1191N, I1227M, V1228L, M1237I, C1243F, P1263L

Overview of Spike Mutations per Variant

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