Peptide Tools to Study Influenza Virus


About the Influenza Virus

Influenza viruses belong to the orthomyxoviridae family. These are enveloped viruses with a segmented, negative-sense, single- stranded RNA genome. Only orthomyxoviridae Influenza type A and B cause disease in humans. Their main antigenic determinants are the two transmembrane proteins hemagglutinin (‘H’ or ‘HA’) and neuraminidase (‘N’ or ‘NA’).
The combinations of specific variants of the H (H1-H18) and N (N1-N11) proteins are used to classify Influenza A viruses into subtypes. The standard WHO nomenclature for a given human influenza virus comprises the genus (‘A’), the geographical site where they were first identified (e.g. Hong Kong), a serial number and the identification year (e.g. 1/1968), and finally the H and N variants.

JPT offers a range of highly relevant Influenza virus-specific antigen peptides, PepMix™ peptide pools and PepStar™ peptide microarrays. Some of these products are listed in the following table, listing egg-based, cell culture-, or recombinant-based vaccines that have been developed in the past years in the northern and southern hemisphere: 

Northern Hemisphere
Egg-based Vaccines
Cell culture- or recombinant-based vaccines
2023-2024
2022-2023
2021-2022
2020-2021
2019-2020


Southern Hemisphere
Egg-based Vaccines
Cell culture- or recombinant-based vaccines
2024
2023
2022
2021
2020




JPT's Influenza Peptide Formats

Cellular Immune Response

PepMix Peptide Pool 
  • Antigen specific stimulation of T-cells
  • Immune monitoring of high-risk patients
  • Identification of immunodominant antigens
  • Validating clinical T-cell assays

  • covers strains from Influenza A such as: H1N1 (Brisbane), H1N1 (California), H1N1 (Puerto Rico), H2N2 (AnnArbor), H3N2 (HongKong), H5N1 (Indonesia), H5N1 (Turkey) and H10N8 (Jiangxi)
  • covers strains from Influenza B such as: H0N0 (Phuket) and H0N0 (Austria)
  • PepMix Ultra Pools reflect sequence variety through specialist and selected peptide sequences

  • T-cell assays
  • High-throughput T-cell epitope discovery
  • Monitoring of cellular immune response

JPT also offers custom-designed PepMix™ Peptide Pools for your specific needs!

Humoral Immune Response

PepStar™ Peptide Microarray
  • Immune monitoring of humoral responses
  • Profiling of Influenza-specific samples or antibodies
  • Detection of epitopes and epitope spreading

You define content and layout, we provide economic and fast production in our regulated clean-room environment.
Ship your samples and obtain high-quality results analysed by experts! We also offer a complete assay and analysis service for your samples using your own, custom-designed peptide microarray.

Clinical Peptides

JPT’s clinical peptide product lines, ‘Clinical Grade’ and ‘ISO Plus’, are produced in a tightly regulated production environment according to an enhanced ISO 9001:2015 quality management system for the stringent product requirements of immunotherapy, vaccine, and drug development. Our products have been approved for clinical use with respect to specific immunotherapeutic applications. 





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References 2023

References 2023

    • Optimising a linear ‘Doggybone’ DNA vaccine for influenza virus through the incorporation of DNA targeting sequences and neuraminidase antigen
      Cunliffe et al., Discovery Immunology (2024) 
      Product used: PepMix Influenza A (Neuroamidase /California (H1N1)
    • Trimeric, APC-Targeted Subunit Vaccines Protect Mice against Seasonal and Pandemic Influenza
      Tjärnhage et al., Journal of Virology (2023) - PMID: 36719241
      Products used: PepMix Influenza A (HA/Puerto Rico/8/1934 H1N1), PepMix Influenza A (HA /California (H1N1))
    • Immunological imprinting of humoral immunity to SARS-CoV-2 in children
      Dowell et al., Nature Communication (2023) - PMID: 37386081
      Products used: PepMix SARS-CoV-2 (Spike B.1.1.529 / BA.1 / Omicron), PepMix Influenza A (MP1 (H3N2))
    • Caracterización del agotamiento de los linfocitos T en pacientes con síndrome Long COVID
      Benéitez, Thesis (2023) 
      Products used: PepMix Influenza A (HA/California (H1N1))custom PepMix for Influenza (HA/Perth (H3N2))
    References Archive

    References Archive

    • Concomitant administration of seasonal influenza and COVID-19 mRNA vaccines
      Aydillo et al., Emerging Microbes & Infections (2023) - PMID: 38054302
      Products used: PepMix Influenza A (HA/H1N1/Victoria/2019)Influenza A (HA/H3N2/Darwin/2021)custom PepMix Influenza B Nucleoprotein
    • Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19
      Kirchner et al., PLoS One (2022) - PMID: 36322587
      Products used: PepMix Pan-SARS-CoV-2 Select, SARS-CoV-2 (Spike Glycoprotein SUB1 & SUB2), SARS-CoV-2 (NCAP), SARS-CoV-2 (VEMP), HCoV-229E (Spike Glycoprotein), HCoV-OC43 (Spike Glycoprotein), HRSVB (Nucleocapsid Protein N), PepMix Influenza A (M1) Ultra
    • Latent CMV Infection Is Associated With Lower Influenza Virus-Specific Memory T-Cell Frequencies, but Not With an Impaired T-Cell Response to Acute Influenza Virus Infection
      Van den Berg, Journal of Immunology (2022) - PMID: 34025665
    • Polyfunctional pathogen-specific CD4+ T cells reside in the lungs and tumors of NSCLC patients
      Oja et al., BioRxiv (2022)
    • A single intranasal dose of human parainfluenza virus type 3-vectored vaccine induces effective antibody and memory T cell response in the lungs and protects hamsters against SARS-CoV-2
      Ilinykh et al., Vaccines (2022) - PMID: 35468973
    • Transcriptional Programs of Neoantigen-Specific TIL in Anti-PD-1-Treated Lung Cancers
      Caushi et al., Nature (2021) - PMID: 34290408
    • M2-Deficient Single-Replication Influenza Vaccine–Induced Immune Responses Associated With Protection Against Human Challenge With Highly Drifted H3N2 Influenza Strain
      Eiden et al., Journal of Infectious Diseases (2021) - PMID: 34323977
    • A Single-Cycle Influenza A Virus-Based SARS-CoV-2 Vaccine Elicits Potent Immune Responses in a Mouse Model
      Koonpaew et al., Vaccines (2021) - PMID: 34451975
    Application Notes

    Application Notes

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