TCR-T Research with PepMix™ Peptide Pools for Key Cancer Targets

T-cell receptor-engineered T-cell therapy (TCR-T) is rapidly gaining momentum in the field of cancer immunotherapy. Unlike CAR-T cells, which recognize surface antigens, TCR-T cells can detect and eliminate cancer cells based on intracellular tumor-associated antigens presented by MHC molecules, offering broader therapeutic opportunities across solid and hematologic malignancies.

A recent comprehensive review (Zhang et al., 2023) highlights the 16 major cancer targets currently pursued in TCR-T clinical trials. JPT is proud to support researchers in this exciting field by offering PepMix™ Peptide Pools for 15 of these 16 critical targets — and a partial PepMix™ for the remaining one (EGFRvIII).

Main TCR-T Targets Available as PepMix™ Peptide Pools:

• AFP (Alpha-fetoprotein) 
• EGFRvIII (partially available as ErbB2-ICD and ErbB2-ECD) 
• EBV (Epstein-Barr Virus) 
• HA-1 
• HBV (Hepatitis B Virus) 
• HPV (Human Papillomavirus) 
• KK-LC-1 
• KRAS (mutated) 
• MAGE-A1 
• MAGE-A3
• MAGE-A4 
• MAGE-A10 
• MART-1 
• Mesothelin 
• NY-ESO-1 
• WT1 

Check all our tumor-associated antigen peptide pools and our more than 1500 individual epitope peptides. 

Why Choose PepMix™ Peptide Pools for TCR-T Research? 

• Comprehensive Antigen Coverage: Each PepMix™ consists of overlapping peptides that span the full protein sequence, ensuring maximal coverage of known and novel epitopes — ideal for discovery, monitoring, and functional assays. 
• High Quality and Batch Consistency: Our optimized synthesis and stringent QC processes guarantee high purity, reproducibility, and biological performance you can trust for clinical research. 
• Experience with Difficult Sequences: Hydrophobic and aggregation-prone sequences? No problem. JPT’s proven expertise ensures even challenging targets are fully represented in your peptide pool. 
• Immediate Availability: More than 450 different catalog PepMix™ peptide pools are available from stock — enabling faster project initiation and smoother workflows. In case we do not have you antigen, contact us! We can provide it to you as a custom PepMix™ Peptide Pool. 

Accelerate Your TCR-T Research 

PepMix™ Peptide Pools are widely used for: 

• Screening TCRs for target specificity 
• Monitoring T-cell responses post-infusion 
• Identifying immunodominant epitopes 
• Supporting preclinical and translational studies   

Advance your TCR-T programs with reliable tools trusted by researchers worldwide and learn more about The World of PepMix™ or contact us!