PepMix™ Peptide Pools for Gene Therapy and Immunogenicity Testing!

Imagine treating diseases by tweaking a person’s genetic code! This is gene therapy in a nutshell. By swapping out faulty genes, silencing malfunctioning genes, or even adding new genes, scientists can tackle complex conditions like hemophilia, cystic fibrosis, and certain immune deficiencies. 

Delivering Genes 

• Naked DNA: Simple, but limited in effectiveness. CRISPR-Cas9 tools breathe new life into this method, although non-human proteins like Cas9 can trigger immune reactions. To monitor and manage these, we have developed a Cas9 PepMix™ peptide pool for effective immune monitoring. 
• Vector-Based Transfer: Viruses such as adenovirus (AdV) and adeno-associated virus (AAV) act as delivery vehicles for gene therapy. We offer a wide variety of different AAV and AdV PepMix™ peptide pools for immune testing against viral proteins like hexon, penton, and capsid proteins. 

Peptide Pools are Key Players for Immune Monitoring & Immunogenicity Testing 

Immunogenicity testing keeps gene therapies safe by ensuring that treatments do not cause unwanted immune responses. Our PepMix™ Peptide Pools are essential tools for immune monitoring and immunogenicity testing. Use them to 

• Track immune responses during gene therapy to measure efficacy. Peptide pools enable detailed assessment of T-cell response with common techniques like ELISpot and ICS. 
• Test for immune responses to viral vectors or proteins like Cas9, to ensure that therapies are as safe as they are effective. 
• Also evaluate a potential immune response towards the expressed therapeutic protein. JPT can produce your target protein in a peptide pool format adapted to ICS or ELIspot immune monitoring. 
• Measure immunogenicity against vector's proteins (Cas9, AAV capsid...) to ensure safety of your vector. A wide range of proteins are available on our catalog and others can be customized. 

See All Peptides for Gene Therapy 

Browse our peptide catalog to find all peptides for gene therapy development, such as Antigen Peptides, Peptide Pools or Peptide Microarrays. 

Did not find what you were looking for? Need a different specification? Send us a quote request! 

The Future is Bright for Gene Therapy! 

Gene therapy is redefining the boundaries of modern medicine, and peptide tools are an essential part of the journey. Whether for immune monitoring, immunogenicity testing, or vaccine development, peptides keep gene therapy moving forward safely and effectively. 

Want to learn more? 

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