Understanding cardiovascular regulation begins with the right research tools. JPT is pleased to introduce our new comprehensive portfolio of high-quality natriuretic peptides, designed to support reproducible research in cardiovascular biology, renal physiology, and related therapeutic areas.
Whether you're studying heart failure, hypertension, receptor signaling, or biomarker development, our peptides provide reliable performance for a wide range of applications.
What Are Natriuretic Peptides?
Natriuretic peptides are naturally occurring peptide hormones that play a critical role in maintaining cardiovascular and fluid homeostasis. The three major family members (Atrial Natriuretic Peptide (ANP), Brain Natriuretic Peptide (BNP), and C-Type Natriuretic Peptide (CNP)) regulate blood pressure and fluid balance by activating natriuretic peptide receptors (NPRs) and stimulating cGMP signaling.
Applications:
Because of these essential physiological roles, natriuretic peptides have become valuable research tools and important biomarkers for cardiovascular disease.
- Cardiovascular research: cardiovascular disease, heart failure, hypertension, myocardial remodeling, vascular biology, and endothelial function
- Renal and metabolic physiology: fluid and electrolyte homeostasis, renal physiology, metabolic disease, and inflammation
- Cell signaling and biomarker research: NP receptor biology, cGMP signaling, biomarker discovery, and diagnostic assay development
- Drug discovery and translational research: therapeutic development, skeletal growth, cartilage biology, and regenerative research
Peptide examples include:
| Peptide | Primary Production Site | Main Receptor Preference | Principal Biological Effects |
| Atrial Natriuretic Peptide (ANP) (1-28) | Cardiac atria | NPR-A | Vasodilation, natriuresis, diuresis |
| Urodilatin, (ANP) (95-126) | Kidney (distal tubules) | NPR-A | Local regulation of sodium and water excretion |
| Brain Natriuretic Peptide (BNP-32) | Cardiac ventricles | NPR-A | Vasodilation, natriuresis, cardiovascular homeostasis |
| C-type Natriuretic Peptide (CNP-22) | Endothilial cell, chondrocytes, and other peripheral tissues | NPR-B | Vascular regulation, endochondral bone growth, tissue remodeling |
Explore JPT's Natriuretic Peptide Portfolio!
Need a peptide that is not listed? Our custom peptide synthesis team can create a tailored solution for your research.