Take Control of Your T cell Assays with PepMix™ Control Pools!

With a portfolio of over 500 products, JPT’s PepMix™ Peptide Pool Catalog remains the largest on the market. We offer a diverse variety of peptide pools tailored for immune monitoring, cellular immune response profiling, or T cell epitope identification, providing unparalleled resources for cutting-edge research in immunotherapy and vaccine development. This week we spotlight our PepMix™ control pools designed to ensure the accuracy and reliability of your T cell assays!

Why Control Pools are Essential 

Immune monitoring of T cell responses plays a central role in the development of immunotherapeutics and vaccines, and thus requires stable positive and negative controls. JPT is proud to offer its own extensive range of peptide-based stimulation controls, along with standardized protocols, and thus facilitating the interpretation of peptide-based T cell stimulation assays. Our control pools feature well-characterized epitope peptides from many common infectious pathogens across different biogeographical ancestries and HLA types. 

At the heart of our catalog, is our most universally applied positive control pool: CEFX Ultra SuperStim Pool. This pool includes 176 peptides, carefully selected from 17 different organisms providing coverage for a broad range of HLA sub-types and different infectious agents that are present in a wide range of ethnic backgrounds. These include clostridium tetani, HaDV5, HHV 1-6, Influenza A, JC polyomavirus and Toxoplasma gondii. 

As a result of the recent COVID-19 pandemic, and the consequential exposure of the virus to humanity, we now offer an updated version of the successful CEFX Ultra SuperStim Pool, which includes 26 SARS-CoV-2 epitopes in addition to the above mentioned 176: CEFXS Ultra SuperStim Pool. 

Both our CEFX and CEFXS Ultra SuperStim Pools are product propietarily developed by JPT. 

Explore Our Full Range of Control Pools 

In addition to the CEFX and CEFSX positive control pools, we also offer a variety of positive and negative control pools designed to meet specific research needs: 

• CEFT Pool (CMV, EBV, Influenza, Tetanus)
• EFX Pool (EBV, Influenza + others)
• CEF Pool & CEF extended (CMV, EBV, Influenza)
• EF Pool (EBV, Influenza)
• CMV pp65
• Human Actin, ACTL8, IG like C1 or MOG 
• eGFP 
• CEFX subsets for MHCI and MHCII 
• Or customize your pool to your requirements! 

Explore Our Online Resources 

Find our PepMix™ application protocol, application notes and publications making use of our control pools in the following list: 

Application Note: "CEFX/EFX Ultra SuperStim Pools: Superior positive controls for T-cell assays with broad MHC-allele and antigen coverage" 

References: 

• Transcriptional signature of durable effector T cells elicited by a replication defective HCMV vaccine
  Ye et al., Vaccines (2024) - PMID: 38561339
  Product used: PepMix™ HCMVA (pp65) 
• Ocrelizumab Alters Cytotoxic Lymphocyte Function While Reducing EBV-Specific CD8+ T-Cell Proliferation in Patients With Multiple Sclerosis
  Abbadessa et al., Neurolog. Neuroimmunology Neuroinflammation (2024) - PMID: 38662990
  Products used: CEFX Ultra SuperStim Pool 
• Secondary bone marrow graft loss after third-party virus-specific T cell infusion: Case report of a rare complication
  Keller et al., Nature Communications (2024) – PMID: 38553461
  Product used: PepMix Human (Actin) 
• A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results
  Rappaport et al., Nature Medicine (2024) - PMID: 38538867
  Product used: CEF Pool (standard) 

Check our guidelines on how to dissolve peptides! 

Contact Us 

Our team of experts is always here to support your research needs. Contact us today to learn how PepMix™ can advance your immune monitoring projects.