MOG Protein: Overview & Peptide Products
Myelin oligodendrocyte glycoprotein (MOG) is a membrane protein associated with oligodendrocytes and the outer surface of myelin in the central nervous system. Its location at the myelin surface makes MOG particularly relevant to research into antigen recognition, neuroimmunology and immune-mediated processes involving myelin.
This protein hub introduces the biological context of MOG and brings together JPT products related to human and mouse MOG. Explore MOG peptides representing defined regions of the protein as well as overlapping formats designed for broader sequence coverage or peptide-resolved analysis.
MOG Protein: Structure and Biological Context
Myelin oligodendrocyte glycoprotein is encoded by the MOG gene and is expressed at the surface of oligodendrocytes and on the outermost surface of myelin sheaths in the central nervous system. Unlike proteins located predominantly within compact myelin, this surface exposure places MOG at the interface between myelin and its surrounding environment.
The extracellular region of the MOG protein contains an immunoglobulin-like domain. Multiple transcript variants and protein isoforms have been described for the human MOG gene, which is relevant when interpreting protein- or sequence-specific experiments.
MOG has consequently become an important protein in neuroscience and immunology research. Experimental approaches may investigate the complete protein, defined amino-acid regions, antigen-specific immune responses or recognition patterns across multiple parts of the MOG sequence. MOG-derived peptides make it possible to reduce this complexity and investigate defined regions of the protein under controlled experimental conditions.
Explore JPT MOG Peptides and Related Products
JPT's MOG portfolio includes defined mouse and human antigen sequences as well as broader human MOG formats. The best choice depends primarily on the organism, whether one defined region or broader sequence coverage is required, and whether multiple sequences should be used together or evaluated individually.
Compare JPT Products for MOG Research
Why Is MOG Important in Research?
The biological location of MOG makes the protein especially relevant to research focused on interactions between myelin and the immune system. MOG has been investigated as an antigen in studies of immune-mediated demyelination and antigen-specific cellular and humoral immune responses.
Different experiments require different levels of sequence resolution. A project focused on a known region may require one defined sequence, while another may need overlapping representation across a larger part of the protein or peptide-resolved comparison of multiple MOG regions.
For this reason, JPT provides MOG peptides and related research formats that address different levels of protein coverage rather than offering one universal MOG reagent.
MOG Research Resources
This protein hub connects the biological context of MOG with JPT's available catalog products and related scientific resources.
Scientific references
Autoimmune research
Custom peptide synthesis