Antigen Peptide MOG - HLA-DRB1*15:01 (MEVGWYRPPFSRVVHLYRNGK)

The human MOG 35-55 peptide, MEVGWYRPPFSRVVHLYRNGK, is a defined human myelin oligodendrocyte glycoprotein antigen peptide with an HLA-DRB1*15:01 restriction listed by JPT. The conventional mature-protein designation 35-55 corresponds to residues 64-84 of the human precursor sequence (UniProt Q16653). This human sequence contains proline at mature residue 42, distinguishing it from the serine-containing mouse counterpart, and supports antigen-specific T-cell research in the appropriate HLA context.

The Human Peptide is a high quality epitope peptide for stimulation of antigen-specific T cells in T cell assays such as ELISPOT, ICS, cytotoxicity or proliferation assays. The Peptide, H-MEVGWYRPPFSRVVHLYRNGK-OH (Uniprot: Q16653 aa: 64-84) from JPT is produced under strict quality control and quality management.

Antigen Peptide MOG - HLA-DRB1*15:01 (MEVGWYRPPFSRVVHLYRNGK) - Specifications

• Peptide sequence: H-MEVGWYRPPFSRVVHLYRNGK-OH
• Amount: 1 mg
• Purity: Trial Grade: each peptide purified to > 90% (HPLC/MS)
• Delivery Format: Freeze-dried in plastic vial
• Application(s):
• Condition(s)/Topic(s):
• Standard Delivery Time: approx. 10 days

Applications

• Stimulation of human MOG-reactive T cells in an HLA-DRB1*15:01-compatible antigen-presentation context.
• ELISpot and intracellular cytokine staining (ICS) to assess responses to the defined human antigen.
• Proliferation assays investigating human MOG-specific T-cell recognition.

Human MOG Antigen Peptide with Defined HLA Context

This product belongs to JPT’s Antigen Peptides and addresses human-sequence-specific immune recognition. Match the peptide sequence and HLA context to the experimental system. Projects requiring the rodent sequence can select the mouse MOG 35-55 peptide.

Human Sequence Identity for Targeted T-Cell Studies

The defined 21-amino-acid sequence allows researchers to test recognition of the human antigen while retaining the biologically relevant proline residue. JPT supplies this variant as 1 mg of freeze-dried peptide with >90% purity by HPLC/MS. Explicit precursor numbering helps connect the product to human protein annotations and published epitope data.

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Discuss project-specific antigen sequences with JPT’s Custom Peptide Synthesis.