Tailored PepStar™ Peptide Microarrays

Applications for PepStar™ Peptide Microarrays:

• Antibody epitope mapping
• Identification & optomization of enzyme substrates
• Screening for protein-protein interactions
• Detection of contaminating enzymes in preparations
  
  

Application Notes:
Download our Application Note on PepStar™ Peptide Microarrays:
"Antibody Signatures Defined by High-Content Peptide Microarray Analyses"
by Schutkowski et al
Download our Application Note on our modular seromarker profiling service:


"A Modular Approach for Epitope Discovery and High-Resolution Profiling of Humoral Immune Responses"
by N. Pawlowski et al

Benefits of PepStar™ Peptide Microarrays:

• Economic provision of large batches of identical microarray copies
• Purified peptides are used
• Consumes only small sample for incubation
• Low background on glass surface
• Read-out via fluorescence
• Screen thousands of potential peptide substrates economically
• Efficient high-throughput screening
• Obtain Peptide ELISAs and custom peptides for validation

Testimonials for PepStar™ Peptide Microarrays:

"The RV 144 HIV trial is considered as one of first successful HIV vaccine trials. It has become clear that the V2 loop of gp120 is an important site for immunogenicity and protection from HIV infection. The use of JPT's PepStar™ microarray technology has been very useful for the correlation of the clincial outcome with humoral immune responses. As have the cyclic peptides been from JPT to validate these findings!"
Jeff Currier, PhD, Walter Reed Army Institute, Rockville, Maryland, USA

"Over the past five years my research team has been active in the development of species-specific peptide arrays. Our ability to advance this technology into new research areas has been dependent on working with the highest quality of arrays. In this regard, JPT’s commitment to excellence has been a critical foundation for the success of our research program.  I have been consistently impressed with their customer service, technical expertise and professionalism. When it comes to peptide work there are no other options for our group…JPT is the best."
Scott Napper, PhD, Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Canada

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Selected References for PepStar™ Peptide Microarrays:

Neutralization of Porcine Endogenous Retrovirus by Antibodies Against the Membrane-Proximal External Region of the Transmembrane Envelope Protein
Waechter et al., J. Gen. Virol. (2013)
Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001)
Barouch et al., J. Infect. Dis. (2013)
Diagnostic Peptide Discovery: Prioritization of Pathogen Diagnostic Markers Using Multiple Features
Carmona et al., PLOS ONE (2012)
The Thai Phase III HIV Type 1 Vaccine Trial (RV144) Regimen Induces Antibodies That Target Conserved Regions Within the V2 Loop of gp120

Karasavvas et al., Aids Research and Human Retroviruses (2012)
Systems Kinomics Demonstrates Congo Basin Monkeypox Virus Infection Selectively Modulates Host Cell Signaling Responses as Compared to West African Monkeypox Virus
Kindrachuk et al., Mol Cell Proteomics (2011)
Clues Emerge to Explain First Successful HIV Vaccine Trial
Ewen Callaway, Nature (2011)
Epitope Mapping of Atlantic Salmon Major Allergen by Peptide Microarray Immunoassay
Perez-Gordo et al., Int Arch Allergy Immunol (2011)
Epitope Mapping of Antibodies to VlsE Protein of Borrelia Burgdorferi in Post-Lyme Disease Syndrome
Chandra, et al., Clin. Immunol. (2011)
Computational Analysis of High-density Peptide Microarray Data with Application from Systemic Sclerosis to Multiple Sclerosis
Hecker et. al, Autoimmunity Reviews (2011)
Antigen Microarrays: Descriptive Chemistry or Functional Immunomics?
Prechl et al., Trends Immunol. (2010)
Humoral Reactome Profiles Using Peptide Microarray Chips
Valentini et al., Trends Immunol. (2010)
Mapping Mouse IL-13 Binding Regions Using Structure Modeling, Molecular Docking, and High-Density Peptide Microarray Analysis
Madala et al., Proteins (2010)
Long-Lived Plasma Cells and Memory B Cells Produce Pathogenic Anti-GAD65 Autoantibodies in Stiff Person Syndrome
Rizzi et al., PloSOne (2010)

More references under JPT Publications/Literature