RepliTope™ peptide microarrays are highly economical tools to detect immunodominant regions in target antigens using overlapping peptide scans displayed on glass slides. Our off-the-shelf RepliTope™ peptide microarrays and our tailored PepStar™ peptide microarrays represent a reliable and efficient source for the characterization of potential therapeutic antibodies, the identification of novel biomarkers, and the elucidation of protein/protein and enzyme/substrate interactions in general.
Moreover, RepliTope™ is applicable for monitoring humoral immune responses using sera in preclinical and clinical trials.
"One focus of our group is to decipher the nature of immune responses by identification of biomarkers and indicators of immune protection. With the support of JPT's high content peptide microarray platform, we created a peptide chip which contains 22.000 individual peptides. This enabled the visualization of the B-cell "signature" in individuals with TB-infection vs. non- infected individuals. In our hands, JPT's peptide microarrays turned out to be very robust tools to identify novel peptide based biomarkers in the context of novel diagnostics and vaccine target identification."
Prof. Markus Maeurer, Karolinska Institute Sweden, Solna, Sweden
More testimonials under JPT Testimonials
Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001)
Barouch et al., J. Immunol. (2012)
Clues Emerge to Explain First Successful HIV Vaccine Trial
Ewen Callaway, Nature (2011)
Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals
Tomaras et al., Journal of Virology (2011)
Long-Lived Plasma Cells and Memory B Cells Produce Pathogenic Anti-GAD65 Autoantibodies in Stiff Person Syndrome
Rizzi et al., PloSOne (2010)
Epitope Mapping Using Randomly Generated Peptide Libraries
Bongartz et al., Methods in Molecular Biology, Epitope Mapping Protocols (2009)
More references under JPT Publications/Literature

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RepliTope™ Peptide Microarrays
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PepStar™ Peptide Microarrays
Microarray Incubation Made Easy-Test our new RepliTope™ Peptide Microarray Incubation Kit now!
(May 2013)
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