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PepTrack™

The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+  T-Cell Response
Mitrovic et al., J. Virol. (2012)
A New Antigen Scanning Strategy for Monitoring HIV-1 Specific T-cell Immune Responses
Manati et al. Journal of Immunological Methods (2012)
Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease
Guettler et al., j.cell (2011)
Immune Responses to Transgene and Retroviral Vector in Patients Treated with Ex Vivo -Engineered T Cells
Lamers et al., Blood (2011)
Integrated NY-ESO-1 Antibody and CD8+ T-cell Responses Correlate with Clinical Benefit in Advanced Melanoma Patients Treated with Ipilimumab
Yuan et al., PNAS (2011)
The Only Proposed T-cell Epitope Derived From the TEL-AML1 Translocation is Not Naturally Processed
Popovic et al., Blood (2011)
Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection
SenGupta et al., J. Virol. (2011)
Telomerase and HER-2/neu as Targets of Genetic Cancer Vaccines in Dogs
Peruzzi et al, Vaccine 28 (2010)
Functional Characterization of Aquaporin-4 Specific T Cells: Towards a Model for Neuromyelitis Optica
Reddy kalluri et. al., PLoS ONE (2011)
Phase I Safety and Immunogenicity Evaluation of MVA-CMDR, a Multigenic, Recombinant Modified Vaccinia Ankara-HIV-1 Vaccine Candidate
Currier et. al., PLoS ONE (2010)
Optimization and Validation of a Robust Human T Cell Culture Method for Monitoring Phenotypic and Polyfunctional Antigen-Specific CD4 and CD8 T-cell Responses
Lin et al., Cytotherapy. (2009)
Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086
Mascioni et al., The Journal of Biological Chemistry (2009)
Comprehensive Analysis of the alpha-Fetoprotein-Specific CD8 T Cell Responses in Patients with Hepatocellular Carcinoma
Thimme, Neagu et al., Hepatology (2008)
Identification and Functional Validation of MHC Class I Epitopes in the Tumor-Associated Antigen 5T4
Shingler et al., International Immunology (2008)
Acquisition of Direct Antiviral Effector Functions by CMV-specific CD4+T Lymphocytes with Cellular Maturation
Casazza et al., J. Exp. Med. (2006)
Novel Method for Detection of Virus-Specific CD4+ T Cells Indicates a Decreased EBV-Specific CD4+ T cell Response in Untreated HIV-Infected Subjects
Piriou et al, Eur. J. Immunol. (2005)

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PepMix™ - Control Pools

A New Antigen Scanning Strategy for Monitoring HIV-1 Specific T-cell Immune Responses
Manati et al. Journal of Immunological Methods (2012)
Polyfunctional T Cells Accumulate in Large Human Cytomegalovirus-Specific T Cell Responses
Lachmann et al., J. Virol. (2012)
Innate and Adaptive Immune Responses Both Contribute to Pathological CD4 T Cell Activation in HIV-1 Infected Ugandans
Eller et al., PLoS ONE (2011)
Correlating Cellular and Molecular Signatures of Mucosal Immunity that Distinguish HIV Controllers from Non-Controllers
Loke et al., Blood (2011)
Generation of a Multipathogen-Specific T-cell Product for Adoptive Immunotherapy Based on Activation-Dependent Expression of CD154
Khanna et al., Blood (2011)
Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection
SenGupta et al., J. Virol. (2011)
A Panel of Human Cell-Based Artificial APC Enables the Expansion of Long-Lived Antigen-Specific CD4+ T Cells Restricted by Prevalent HLA-DR Alleles
Butler et al., Int. Immunol. (2010)
AdCD40L Immunogene Therapy for Bladder Carcinoma—The First Phase I/IIa Trial
Malmström et al., Clin. Cancer Res. (2010)
Intense Antiextracellular Adaptive Immune Response to Human Cytomegalovirus in Very Old Subjects with Impaired Health and Cognitive and Functional Status
Vescovini et al., J. Immunol. (2010)
Human Late Memory CD8+ T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production
St. Johns et al., J. Immunol. (2009)
The Transfer of Adaptive Immunity to Cytomegalovirus (CMV) During Hematopoietic Stem Cell Transplantation is Dependent on the Specificity and Phenotype of CMV-Specific T Cells in the Donor
Scheinberg et al., Blood (2009)
T Cell Infiltrates in the Muscles of Patients with Dermatomyositis and Polymyositis Are Dominated by CD28null T Cells
Fasth et al.,  J. Immunol. (2009)
Identification and Characterization of IL-10/IFN-gamma-Producing Effector-Like T cells with Regulatory Function in Human Blood
Haringer et al., J. Exp. Med. (2009)
Enumeration of Cytomegalovirus-Specific Interfering CD8+ and CD4+ T Cells Early After Allogeneic Stem Cell Transplantation May Identify Patients at Risk of Active Cytomegalovirus Infection
Solano et al., Haematologica (2008)
Clonotype Analysis of Cytomegalovirus-Specific Cytotoxic T Lymphocytes
Babel et al., JASN Express (2008)
Type I IFN-Induced, NKT Cell-Mediated Negative Control of CD8 T Cell Priming by Dendritic Cells1
Bochtler et al., The Journal of Immunology (2008)
Prophylactic Infusion of Cytomegalovirus Specific Cytotoxic T-lymphocytes Stimulated with Ad5f35pp65 Gene Modified Dendritic Cells Following Allogeneic Haemopoietic Stem Cell Transplantation
Micklethwaite et al., Blood (2008)

Massive Load of Functional Effector CD4+ and CD8+ T Cells against Cytomegalovirus in Very Old Subjects
Viscovini et al., J Immunol. (2007)
Longitudinal Assessment of Cytomegalovirus (CMV)–Specific Immune Responses in Liver Transplant Recipients at High Risk for Late CMV disease
La Rosa et al., The Journal of Infectious Diseases (2007)
No Evidence for Circulating HuD-Specific CD8+ T Cells in Patients with Paraneoplastic Neurological Syndromes and Hu Antibodies
De Beukelaar et al., Cancer Immunol Immunother (2007)
The T Cell Response to Persistent Herpes Virus Infections in Common Variable Immunodeficiency
Raeiszadeh et al., British Society for Immunology, Clinical and Experimental Immunology (2006)
Monoculture-Derived T lymphocytes Specific for Multiple Viruses Expand and Produce Clinically Relevant Effects in Immunocompromised Individuals
Leen et al., Nature Medicine (2006)
Direct Access to CD4+ T Cells Specific for Defined Antigens According to CD154 Expression
Frentsch et al., Nat Med. (2005)
HLA Type-Independent Generation of Antigen-Specific T Cells for Adoptive Immunotherapy
Hammer et al., Eur. J. Immunol. (2005)

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PepMix™ - Infectious Diseases

T-cell Therapy for EBV-Associated Nasopharyngeal Carcinoma: Preparative Lymphodepleting Chemotherapy Does not Improve Clinical Results
Secondino et al., Ann. Onc. (2012)
A Whole Blood Monokine-based Reporter Assay Provides a Sensitive and Robust Measurement of the Antigen-Specific T Cell Response
Chakera et al., Journal of Translational Medicine (2011)
Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children
Hoft et al., The Journal of Infectious Disease (2011)
Rebound of Residual Plasma Viremia After Initial Decrease Following Addition of Intravenous Immunoglobulin to Effective Antiretroviral Treatment of HIV
Mellberg et al., AIDS Research and Therapy (2011)
A Phase II Study Evaluating the Safety and Efficacy of an Adenovirus-LMP1-LMP2 Transduced Dendritic Cell Vaccine in Patients with Advanced Metastatic Nasopharyngeal Carcinoma
Chia et al. Ann. Onc. (2011)
T-cell Therapy for EBV-Associated Nasopharyngeal Carcinoma: Preparative Lymphodepleting Chemotherapy Does Not Improve Clinical Results
Secondino et al., Ann. Onc. (2011)
Polyomavirus BK Large T-antigen Derived Peptide Elicits a HLA-DR Promiscuous and Polyfunctional CD4+ T-cell Response
Ramaswami et al., Clin. Vaccine Immunol (2011)
Expansion of T Cells Targeting Multiple Antigens of Cytomegalovirus, Epstein – Barr Virus and Adenovirus to Provide Broad Antiviral Specificity After Stem Cell Transplantation
Hanley et al, Cytotherapy (2011)
Adoptive Transfer of EBV-specific T Cells Results in Sustained Clinical Responses in Patients With Locoregional Nasopharyngeal Carcinoma
Louis et al., J Immunother (2010)
Effective and Long-term Control of EBV PTLD After Transfer of Peptide-Selected T Cells
Moosmann et al, BLOOD (2010)
Accelerated Production of Antigen-Specific T-cells for Pre-Clinical and Clinical Applications Using Gas-permeable Rapid Expansion Cultureware (G-Rex)
Vera et al., J Immunother. 2010
Derivation of Human T Lymphocytes From Cord Blood and Peripheral Blood with Antiviral and Antileukemic Specificity from a Single Culture as Protection Against Infection and Relapse after Stem Cell Transplantation
Micklethwaite et al., Blood (2010)
Absence of Systemic Immune Response to Adenovectors After Intraocular Administration to Children With Retinoblastoma
Ildefonso et al., Molecular Therapy (2010)
Nucleofection of DCs to Generate Multivirusspecific T Cells for Prevention or Treatment of Viral Infections in the Immunocompromised Host
Gerdemann et al., Molecular Therapy (2009)
Cytotoxic T Lymphocyte Therapy with Donor T Cells Prevents and Treats Adenovirus and Epstein-Barr Virus Infections after Haploidentical and Matched Unrelated Stem Cell Transplantation
Leen et al., Blood (2009)
Tuberculosis Subunit Vaccination Provides Long-Term Protective Immunity Characterized by Multifunctional CD4 Memory T Cells
Lindenstrom et al. J. Immunol (2009)
Enhancing the In Vivo Expansion of Adoptively Transferred EBV-Specific CTL with Lymphodepleting CD45 Monoclonal Antibodies in NPC Patients
Louis et al., Blood (2009)
Mesenchymal Stem Cells Exert Differential Effects on Alloantigen and Virus-Specific T-cell Responses
Karlsson et al., Blood (2008)
Prospective Monitoring of Polyomavirus BK Replication and Impact of Pre-Emptive Intervention in Pediatric Kidney Recipients
Ginevri et al., American Journal of Transplantation (2007)
Contact-activated Monocytes: Efficient Antigen Presenting Cells for the Stimulation of Antigen-specific T cells
Leen et al., J Immunother  (2007)

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PepMix™ - Tumor Associated Antigen pools

Cytotoxic T Lymphocytes Simultaneously Targeting Multiple Tumor-associated Antigens to Treat EBV Negative Lymphoma
Gerdemann et al., Molecular Therapy (2011)
Improving T-cell Therapy for Relapsed EBV-Negative Hodgkin Lymphoma by Targeting Upregulated MAGE-A4
Cruz et al., Clin. Cancer Res. (2011)
Prophylactic Transfer of BCR-ABL–, PR1-, and WT1-Reactive Donor T Cells after T cell–Depleted Allogeneic Hematopoietic Cell Transplantation in Patients with Chronic Myeloid Leukemia
Bornhäuser et al., Blood. (2011)
Induction of Complete and Molecular Remissions in Acute Myeloid Leukemia by Wilms’ Tumor 1 Antigen-Targeted Dendritic Cell Vaccination
Tendeloo et al., PNAS (2010)
Antigen-Specific Cytotoxic T Lymphocytes can Target Chemoresistant Side-Population Tumor Cells in Hodgkin’s Lymphoma
Shafer et al., Leuk Lymphoma. (2010)
High-Avidity Cytotoxic-T-lymphocytes Specific for a New Preferentially Expressed antigen of Melanoma (PRAME)-Derived Peptide can Target Leukemic- and Leukemic-precursor Cells
Quintarelli et al. Blood (2010)
Optimization and Validation of a Robust Human T Cell Culture Method for Monitoring Phenotypic and Polyfunctional Antigen-Specific CD4 and CD8 T-cell Responses
Lin et al., Cytotherapy. (2009)
MMP11: A Novel Target Antigen for Cancer Immunotherapy
Peruzzi et al. Clin Cancer Res (2009)
Induction of Wilms' Tumor Protein (WT1)-Specific Antitumor Immunity Using a truncated WT1-Expressing Adenovirus Vaccine
Osada et al. Clin. Cancer Res. (2009)
AtPTR1 and AtPTR5 Transport Sipeptides in Planta
Komarova et al, Plant Physiology Preview (2008)
The Wilms' Tumor Antigen is a Novel Target for Human CD4 Regulatory T Cells: Implications for Immunotherapy
Lehe et al.,  Cancer Res. (2008)
Three-Dimensional MR Mapping of Angiogenesis with 5 1(3)-targeted Theranostic Nanoparticles in the MDA-MB-435 Xenograft Mouse Model
Schmieder et al., The FASEB Journal (2008)
Complete Responses of Relapsed Lymphoma Following Genetic Modification of Tumor-Antigen Presenting Cells and T-lymphocyte Transfer
Bollard et al., Blood (2007)
An MVA Vaccine Overcomes Tolerance to Human p53 in Mice and Humans
Song et al., Cancer Immunol Immunother (2007)

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PepStar™

Systems Kinomics Demonstrates Congo Basin Monkeypox Virus Infection Selectively Modulates Host Cell Signaling Responses as Compared to West African Monkeypox Virus
Kindrachuk et al., Mol Cell Proteomics (2011)
Clues Emerge to Explain First Successful HIV Vaccine Trial
Ewen Callaway, Nature (2011)
Polyclonal B Cell Responses to Conserved Neutralization Epitopes in a Subset of HIV-1-Infected Individuals
Tomaras et al., Journal of Virology (2011)
Epitope Mapping of Atlantic Salmon Major Allergen by Peptide Microarray Immunoassay
Perez-Gordo et al., Int Arch Allergy Immunol (2011)
Epitope Mapping of Antibodies to VlsE Protein of Borrelia Burgdorferi in Post-Lyme Disease Syndrome
Chandra, et al., Clin. Immunol. (2011)
Parvulin 17 Promotes Microtubule Assembly by Its Peptidyl-Prolyl Cis/Trans Isomerase Activity
Thiele et al., J. Mol. Biol. (2011)
Impact of Valency of a Glycoprotein B Specific Monoclonal Antibody on Neutralization of Herpes Simplex Virus
Krawczyk et al., J. Virol. (2011)
The Protein Interaction Network Mediated by Human SH3 Domains
Carducci et al., Biotechnol Adv (2011)
Computational Analysis of High-density Peptide Microarray Data with Application from Systemic Sclerosis to Multiple Sclerosis
Hecker et. al, Autoimmunity Reviews (2011)
Identification of New Substrates of the Protein Tyrosine Phosphatase PTP1B by Bayesian Integration of Proteome Evidence
Ferrari et al., J. Biol. Chem. (2011) 
Antigen Microarrays: Descriptive Chemistry or Functional Immunomics?
Prechl et al., Trends Immunol. (2010)
Humoral Reactome Profiles Using Peptide Microarray Chips
Valentini et al., Trends Immunol. (2010)
Mapping Mouse IL-13 Binding Regions Using Structure Modeling, Molecular Docking, and High-Density Peptide Microarray Analysis
Madala et al., Proteins (2010)
Long-Lived Plasma Cells and Memory B Cells Produce Pathogenic Anti-GAD65 Autoantibodies in Stiff Person Syndrome
Rizzi et al., PloSOne (2010)
Greater Epitope Recognition of Shrimp Allergens by Children than Adults Suggests that Shrimp Sensitization Decreases with Age
Ayuso et al, J. Allergy Clin. Immunol. (2010)
Correlation of IgE/IgG4 milk epitopes and affinity of milkspecific IgE antibodies with different phenotypes of clinical milk allergy
Wang et al., American Academy of Allergy, Asthma & Immunology (2010)
Epitope Mapping Using Randomly Generated Peptide Libraries
Bongartz et al., Methods in Molecular Biology, Epitope Mapping Protocols (2009)
Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1
Zhang et al., J. Biol. Chem.(2009)
Peptide Microarray – Based Identification of Mycobacterium Tuberculosis Epitope Binding to HLADRB1*0101, DRB1*1501 and DRB1*0401
Gaseitsiwe et al., Clin. Vaccine Immunol. (2009)
Development of a Novel Peptide Microarray for Large-Scale Epitope Mapping of Food Allergens
Lin et al., The Journal of allergy and clinical immunology (2009)
Tumor Suppressor Density-Enhanced Phosphatase-1 (dep-1) Inhibits the Ras Pathway by Direct Dephosphorylation of ERK1/2 Kinases
Sacco et al., The Journal of Biological Chemistry (2009)
Probing the Epitope Signatures of IgG Antibodies in Human Serum from Patients with Autoimmune Disease
Lorenz et al. Methods in Molecular Biology, Epitope Mapping Protocols (2009)
Peptide Microarrays for Profiling of Modification State-Specific Antibodies
Zerweck et. al. Methods in Molecular Biology, Epitope Mapping Protocols (2009)
Major Histocompatibility Complex Class II Molecule-Human Immunodeficiency Virus Peptide Analysis Using a Microarray Chip
Gaseitsiwe et al., Clin. Vaccine Immunol. (2009)
Identification and Testing of Control Peptides for Antigen Microarrays
Ngo et al., Journal of Immun. Methods (2009)
Phase 2 Trial of a DNA Vaccine Encoding Myelin Basic Protein for Multiple Sclerosis
Garren et al., Ann Neurol (2008)
Crystal Structure and Functional Analysis of the Protein-Disulfide Isomerase Related Protein ERp29
Barak et al., Journal of Molecular Biology (2008)
Mapping of the IgE and IgG4 Sequential Epitopes of Milk Allergens with a Peptide Microarray–Based Immunoassay
Ceredero et al., American Academy of Allergy, Asthma & Immunology (2008)
Prion Recognition Elements Govern Nucleation, Strain Specificity and Species Barriers
Tessier et al., Nature (2008)
Validation of Peptide Epitope Microarray Experiments and Extraction of Quality Data
Nathman et al., Journal of Immunological, Methods (2007)
NMDA Receptor Activation Dephosphorylates AMPA Receptor Glutamate Receptor 1 Subunits at Threonine 840
Delgado et. al, The Journal of Neuroscience (2007)

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PepSpots™

Urinary FSP1 Is a Biomarker of Crescentic GN
Iwano et al., J. Am. Soc. Nephrol. (2012)
Type III Restriction Endonuclease EcoP15I is a Heterotrimeric Complex Containing one Res Subunit with Several DNA-binding Regions and ATPase Activity
Wyszomirski et al., Nucleic Acids Res. (2011)
Interaction Studies between the Chloroplast Signal Recognition Particle Subunit cpSRP43 and the Full-length Translocase Alb3 Reveal a Membrane-embedded Binding Region in Alb3 Protein
Dünschede et al., J. Biol. Chem. (2011)
Molecular Basis for the Unique Role of the AAA  Chaperone ClpV in Type VI Protein Secretion
Pletrosluk et al., Journal of Biological Chemistry (2011)
PTB Domain-Directed Substrate Targeting in a Tyrosine Kinase from the Unicellular Choanoflagellate Monosiga brevicollis
Prieto-Echague et al., PLoS ONE (2011)
Protein Kinase CK2 Regulates the Formation and Clearance of Aggresomes in Response to Stress
Watabe et al., J. Cell Sci. (2011)
HSP70 Natively and Specifically Associates with an N-terminal Dermcidin-derived Peptide That Contains an HLA-A*03 Antigenic Epitope
Stocki et al., J. Biol. Chem. (2011)
A Robust Protocol to Map Binding Sites of the 14-3-3 Interactome: Cdc25C Requires Phosphorylation of Both S216 and S263 to bind 14-3-3
Chan et al., Mol. Cell. Proteomics. (2011)
Biological Effects and Use of PrPSc- and PrP-Specific Antibodies Generated by Immunizing with Purified Full Length Native Mouse Prions
Petsch et al., J. Virol. (2011)
Cardiac Troponin T, a Sarcomeric AKAP, Tethers Protein Kinase A at the Myofilaments
Sumandea et al., J. Biol. Chem. (2011)
Inhibiting a-Synuclein Oligomerization by Stable Cell-Penetrating b-Synuclein Fragments Recovers Phenotype of Parkinson’s Disease Model Flies
Shaltiel-Karyo et al. PloS ONE (2010)
Binding of the Human Complement Regulators CFHR1 and Factor H by Streptococcal Collagen-like Protein 1 (Scl1) via Their Conserved C Termini Allows Control of the Complement Cascade at Multiple Levels
Reuter et al., The Journal of biological Chemistry (2010)
Identification of Potential HLA Class I and Class II Epitope Precursors Associated with Heat Shock Protein 70 (HSPA)
Stocki et al., Cell Stress Chaperones (2010)
A Monoclonal Antibody Against Mutated Nucleophosmin 1 for the Molecular Diagnosis of Acute Myeloid Leukemias
Gruszka et al. Blood 2010
Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1act/Tubulin Interaction is an Important Determinant of Mitotic Stability in Cultured HT1080 Human Fibrosarcoma Cells
Cao et al, Cancer Res. (2010)
N-terminal Acetylation of Cellular Proteins Creates Specific Degradation Signals
Hwang HS et al, Science 2010
Multiple Molecules of Hsc70 and a Dimer of DjA1 Independently Bind to an Unfolded Protein
Terada et al., J. Biol. Chem. (2010)
CD36 Is a Novel Serum Amyloid A (SAA) Receptor Mediating SAA Binding and SAA-induced Signaling in Human and Rodent Cells
Baranova et al., J. Biol. Chem. (2010)
Potent High-Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Cells of Infected Patients
Collarini et al., J. Immunol. (2009)
Regulation of IRSp53-Dependent Filopodial Dynamics by Antagonism Between 14-3-3 Binding and SH3-Mediated Localization
Robens et al, Mol. Cell. Biol. (2009)
Accurate Prediction of DnaK-Peptide Binding via Homology Modelling and Experimental Data
Van Durme et al., PLoS Computational Biology (2009)
A Two-Hit Mechanism Causes Cerebral Cavernous Malformations: Complete Inactivation of CCM1, CCM2 or CCM3 in Affected Endothelial Cells
Pagenstecher et al., Human Molecular Genetics (2009)
Interaction of the Periplasmic Prata Factor And The PSBA (D1) Protein During Biogenesis of Photosystem Ii in Synechocystis Sp.Pcc 6803
Schottowksi et al., The Journal of Biological Chemistry (2009)
SAP18 Promotes Kruppel-dependent Transcriptional Repression by Enhancer-specific Histone Deacetylation
Matyash et al., The Journal of Biological Chemistry (2009)
Crystal Structure and Functional Analysis of the Protein-Disulfide Isomerase Related Protein ERp29
Barak et al., Journal of Molecular Biology (2008)
The Structure and Interactions of the Proline-rich Domain of ASPP2
Rotem et al., The journal of Biological Chemistry (2008)
The P-113 Fragment of Histatin 5 Requires a Specific Peptide Sequence for Intracellular Translocation in Candida albicans, Which Is Independent of Cell Wall Binding
Jang et al., Antimocrobial Agents and Chemotherapy (2008)
The B-cell Epitope of the Monoclonal Anti-Factor VIII Antibody ESH8 Characterized by Peptide Array Analysis
Albert et al., Thromb Haemost Vol. 99 (2008)
Sap18 promotes Kruppel-Dependent Transcriptional Repression by Enhancer Specific Histone Deacetylation
Matyash et al., J Biol Chem. (2008)
Uptake of the Antifungal Cationic Peptide Histatin 5 by Candida Albicans Ssa2p Requires Binding to Non-Conventional Sites Within the ATPase Domain
Sun et al., Molecular Microbiology (2008)
Molecular Basis of the Interaction Between the Antiapoptotic Bcl-2 Family Proteins and the Proapoptotic Protein ASPP2
Katz et al., PNAS (2008)
The Essential Function of Tim12 in Vivo is Wnsured by the Assembly Interactions of Its C-terminal Domain
Lionaki et al., The Journal of Biological Chemistry (2008)
Generation and Characterization of a Recombinant Antibody Fragment That Binds to the Coat Protein of Grapevine Leafroll-Associated Virus 3
Orecchia et al., Arch. Virol. (2008)
Molecular Determinants for the Recruitment of the Ubiquitin-Ligase MuRF-1 onto M-line Titin
Mrozek et al., The FASEB Journal (2007)
Dynamics of Protein Kinase C-mediated Phosphorylation of the Complement C5a Receptor on Serine 334 Pollok-Kopp et al., The Journal of Biological Chemistry (2007)
Isolation and Comparative Characterization of Ki-67 Equivalent Antibodies from the HuCAL Phage Display Library
Biol. Chem., Jarutat et al. (2006)
The Cell-Cycle Regulator Geminin Inhibits Hox Function Through Direct and Polycomb-Mediated Interactions
Luo et al., Nature (2004)
Identifica

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Specialty Peptides

Self-Reactive Human CD4 T Cell Clones Form Unusual Immunological Synapses
Schubert et al., J. Exp. Med.(2012)
The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+  T-Cell Response
Mitrovic et al., J. Virol. (2012)
The Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) Influences Platelet Calcium Signaling and Function by Regulation of Orai1 Expression in Megakaryocytes
Borst el al., Blood (2012)
Wilms’ Tumor 1-specific Cytotoxic T Lymphocytes Can be Expanded from Adult Donors and Cord Blood
Krishnadas et al., Leukemia Research (2011)
Tim50’s Presequence Receptor Domain Is Essential for Signal Driven Transport Across The TIM23 Complex
Schulz et al., J. Cell Biol. (2011)
Differentiation of CD8+ T cells Into Effector Cells is Enhanced by Physiological Range Hyperthermia
Mace et al., J. Leukoc. Biol. (2011)
Cytoplasmic N-Glycosyltransferase of Actinobacillus pleuropneumoniae Is an Inverting Enzyme and Recognizes the NX(S/T) Consensus Sequence
Schwarz et al., J. Biol. Chem. (2011)
Chemokine Nitration Prevents Intratumoral Infiltration of Antigen-Specific T cells
Molon et al., J. Exp. Med. (2011)
Functional Gap Junctions Accumulate at the Immunological Synapse and Contribute to T Cell Activation
Mendoza-Naranjo et al., J. Immunol. (2011)
The Immunodominant CD8 T Cell Response to the Human Cytomegalovirus Tegument Phosphoprotein pp65495–503 Epitope Critically Depends on CD4 T Cell Help in Vaccinated HLA-A*0201 Transgenic Mice
Reiser et al., J. Immunol. (2011)
A Whole Blood Monokine-based Reporter Assay Provides a Sensitive and Robust Measurement of the Antigen-Specific T Cell Response
Chakera et al., Journal of Translational Medicine (2011)
Induction of HLA-DP4–Restricted Anti-Survivin Th1 and Th2 Responses Using an Artificial Antigen-Presenting Cell
Tanaka et al., Clin. Cancer Res. (2011)
Live and Inactivated Influenza Vaccines Induce Similar Humoral Responses, but Only Live Vaccines Induce Diverse T-Cell Responses in Young Children
Hoft et al., The Journal of Infectious Disease (2011)
Sequence-Specific Long Range Networks in PSD-95/Discs Large/ZO-1 (PDZ) Domains Tune Their Binding Selectivity
Gianni et al., J. Biol. Chem. (2011)
Processing of HEBP1 by Cathepsin D Gives Rise to F2L, the Agonist of Formyl Peptide Receptor 3
Devosse et al., J. Immunol. (2011)
SCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells
Duewell et al., J. Immunol. (2011)
Cross-protective TH1 Immunity Against Aspergillus Fumigatus and Candida Albicans
Stuehler et al., Blood (2011)
Memory CD4 T Cells That Express CXCR5 Provide Accelerated Help to B Cells
MacLeod et al., J. Immunol. (2011)
Highly Specific Auto-antibodies Against Claudin-18 Isoform 2 Induced by a chimeric HBcAg Virus-like Particle Vaccine Kill Tumor Cells and Inhibit the Growth of Lung Metastases
Klamp et al., Cancer Res. (2011)
Splice Variants of the Dual Specificity Tyrosine Phosphorylation-regulated Kinase 4 (DYRK4) Differ in Their Subcellular Localization and Catalytic Activity
Papadopoulos et al., J. Biol. Chem. (2011)
HLA-A*3001 and A*3002 Show Distinct Peptide Binding Patterns of The Mycobacterium Tuberculosis Protein TB10.4: Consequences for Immune Recognition
Axelsson-Robertson et al. Clin. Vaccine Immunol. (2010)
Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity
Kreiter, et al. Cancer Res. (2010)
Active Immunization with Amyloid-β 1–42 Impairs Memory Performance through TLR2/4-Dependent Activation of the Innate Immune System
Vollmar et al., J. Immunol. (2010)
Cleavage Site Specificity of MMP-20 for Secretory-stage Ameloblastin
Chun et al., Journal of Dental Research. (2010)
Immunologic Response to Xenogeneic gp100 DNA in Melanoma Patients: Comparison of Particle-Mediated Epidermal Delivery with Intramuscular Injection
Brian et al., Clin. Cancer Res. (2010)
The adaptor molecule CARD9 is essential for tuberculosis control
Dorhoi et al., J. Exp. Med. (2010)
Autophosphorylation of Polo-like Kinase 4 and Its Role in Centriole Duplication
Sillibourne et al. Mol. Biol. Cell. (2010)
Mechanism of Amyloid Plaque Formation Suggests an Intracellular Basis of Aβ Pathogenicity
Friedrich et al., PNAS (2010)
Highly Diverse Cyanobactins in Strains of the Genus Anabaena
Leikovski et al., Appl. Envir. Microbiol. (2010)
T Cells Are Required for the Production of Blister-Inducing Autoantibodies in Experimental Epidermolysis Bullosa Acquisita
Sitaru et al., J. Immunol. (2010)
Disease-Causing Mutations Within the Lysosomal Integral Membrane Protein Type 2 (LIMP-2) Reveal the Nature of Binding to its LigandBeta-Glucocerebrosidase
Blanz et al., Hum. Mol. Genet.(2010)
Immune Evasion Proteins of Murine Cytomegalovirus Preferentially Affect Cell Surface Display of Recently Generated Peptide Presentation Complexes
Lemmermann et al, J. Virol. (2010)
In vivo Administration of Artificial Antigen-Presenting Cells Activates Low-Avidity T Cells for Treatment of Cancer
Ugel et al., Cancer Res. (2009)
Novel Mediators of Amyloid Precursor Protein Signaling
Swistowski et al., J. Neurosci. (2009)
DNA beta-Amyloid1-42 Trimer Immunization for Alzheimer Disease in a Wild-Type Mouse Model
Lambracht-Washington et al., JAMA, (2009)
Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium
Berchtold et al. Infection and Immunity (2009)
Immune Evasion Proteins of Murine Cytomegalovirus Preferentially Affect Cell Surface Display of Recently-Generated Peptide Presentation Complexes
Lemmermann et al., J. Virol. (2009)
Regulation of the Interaction Between Protein Kinase C-related Protein Kinase 2 (PRK2) and Its Upstream Kinase, 3-Phosphoinositide-dependent Protein Kinase 1 (PDK1)
Dettori et al., The Journal of Biological Chemistry (2009)
Structural Basis for Ca2+ -Independence and Activation by Homodimerization of Tomato Subtilase 3
Ottmann et al., PNAS (2009)
Mmp-20 and Klk4 Cleavage Site Preferences for Amelogenin Sequences
Nagano et al., Journal of Dental Research (2009)
Elimination of Immunodominant Epitopes from Multispecific DNA-Based Vaccines Allows Induction of CD8 T Cells That Have a Striking Antiviral Potential
Riedl et al., The Journal of Immunology (2009)
The D816V Mutation Of C-Kit Circumvents a Requirement for SRC Family Kinases in C-Kit Signal Transduction
Sun et al., The Journal of Biological Chemistry (2009)
Immunogenicity and Protective Efficacy of Prime-Boost Regimens with Recombinant ureC hly Mycobacterium bovis BCG and Modified Vaccinia Virus Ankara Expressing M. tuberculosis Antigen 85A against Murine Tuberculosis
Tchilian et al., Infection and Immunity (2009)
AtPTR1 and AtPTR5 Transport Dipeptides in Planta1
Komarova et Al., Plant Physiology (2008)
Three-Dimensional MR Mapping of Angiogenesis with 5 1( 3)-Targeted Theranostic Nanoparticles in the MDA-MB-435 Xenograft Mouse Model
Schmieder et al., The FASEB Journal (2008)
Identification and Functional Validation of MHC Class I Epitopes in the Tumor-Associated Antigen 5T4
Shingler et al., International Immunology (2008)
Magnitude, Breadth, and Functional Profile of T-Cell Responses during Human Immunodeficiency Virus Primary Infection with B and BF Viral Variants
Turk et al., Journal of Virology (2008)
Impact of MHC Class I Alleles on the M. Tuberculosis Antigen-Specific CD8þ T-cell Response in Patients with Pulmonary Tuberculosis
Weichold et al., Genes and Immunity (2007)
A Fluorogenic Substrate as Quantitative in vivo Reporter to Determine Protein Expression and Folding of Tobacco Etch Virus Protease in Escherichia Coli
Kraft et al., Protein Expression and Purification (2007)
Cross-Reactive T-Cell Responses to the Nonstructural Regions of Dengue Viruses among Dengue Fever and Dengue Hemorrhagic Fever Patients in Malaysia
Appanna et al., CLINICAL AND VACCINE IMMUNOLOGY (2007)
Vaccination with Prion Peptide-Displaying Papillomavirus-like Particles Induces Autoantibodies to Normal Prion Protein that Interfere with Pathologic Prion Protein Production in Infected Cells
Handisurya et al., FEBS Journal (2007)
Folding and Unfolding of a Photoswitchable Peptide from Picoseconds to Microseconds
Ihalainen et al., PNAS Vol. (2007)
Papillomavirus-Like Particles are an Effective Platform for Amyloid-beta Immunization in Rabbits and Transgenic Mice
Zamora et al., J Immunol. (2006)
A DNA Spiegelmer to Staphylococcal Enterotoxin
B Purschke et al., Nucleic Acids Research (2003)
Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62Llo Memory-Effector Cell Pool during Latent Murine Cytomegalovirus Infection of the Lungs
Holtappels et al., J. Virol. (2000)

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Enzyme Profiling Tools

Kinase Peptide Microarrays
Systems Kinomics Demonstrates Congo Basin Monkeypox Virus Infection Selectively Modulates Host Cell Signaling Responses as Compared to West African Monkeypox Virus
Kindrachuk et al., Mol Cell Proteomics (2011)
Computational Prediction and Experimental Verification of New MAP Kinase Docking Sites and Substrates Including Gli Transcription Factors
Whisenant et al, PLoS Computational Biology (2010)
Peptide Arrays for Enzyme Profiling
Thiele et al., Methods Mol. Biol. (2009)
Genome to Kinome: Species-Specific Peptide Arrays for Kinome Analysis
Jalal et al., Science Signaling (2009)
Identification of Candidate Substrates for Ectodomain Shedding by the Metalloprotease-Disintegrin ADAM8
Schutkowski et al., ChemBioChem (2005)
Substrate Specificity Analysis of Protein Kinase Complex Dbf2-Mob1 by Peptide Library and Proteome Array Screening
Mah et al., Biochemistry (2005)
Molecular Basis for the Substrate Specificity of NIMA-related Kinase-6 (NEK6)
Lizcano et al., J. Biol. Chem. (2002)

Phosphatase Substrate Set
Characterization of the Catalytic Activity of the Membrane-anchored Metalloproteinase ADAM15 in Cell-based Assays
Maretzky et al., Biochem. J. (2009)
Protein-tyrosine Phosphatase H1 Controls Growth Hormone. Receptor Signaling and Systemic Growth
Pilecka et al., The journal of Biological Chemistry (2007)

Phophatase Peptide Microarrays
Diverse Driving Forces Underlie the Invariant Occurrence of the T42A, E139D, I282V and T468M SHP2 Amino Acid Substitutions Causing Noonan and LEOPARD Syndromes
Martinelli et al., Human Molecular Genetics (2008)

Phosphorylation Site Detector
Side Chain Specificity of ADP-Ribosylation by a Sirtuin
Fahie et al., FEBS Journal (2009)
High-Density Peptide Microarrays for Reliable Identification of Phosphorylation Sites and Upstream Kinases
Thiele et al., Methods Mol Biol. (2009)
Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks
Coba et al., Science Signaling (2009)

Protease Peptide Microarrays
Chapter 2: Fluorescence-Based Biochemical Protease Assays Formats
Woelcke et al., A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery (2010)

Protease Spots
Identification of Candidate Substrates for Ectodomain Shedding by the Metalloprotease-Disintegrin ADAM8
Naus et al., Biol. Chem. (2006)

Protease Substrate Sets
Proteolytic Cleavage of Covalently Linked Cell Wall Proteins by Candida Albicans Sap9 and Sap10
Schild et al., Eukaryot. Cell (2010)

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Bioinformatics: Library Design, Data Mining & Evaluation

Probing the Epitope Signatures of IgG Antibodies in Human Serum from Patients with Autoimmune Disease
Lorenz et al., Methods Mol. Biol. (2009)
Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip Analysis Representing 61 Proteins from M. tuberculosis
Gaseitsiwe et al., PLoS One (2008)
Validation of Peptide Epitope Microarray Experiments and Extraction of Quality Data
Nahtman et al., J. Immunol. Methods (2007)
Affinity Profiling Using the Peptide Microarray Technology: a Case Study
Tapia et al., Anal. Biochem. (2007)
High-Content Peptide Microarrays for Deciphering Kinase Specificity and Biology
Schutkowski et al., Angew. Chem. Int. Ed. Engl. (2004)
Target Specificity Analysis of the Abl Kinase Using Peptide Microarray Data
Rychlewski et al., J. Mol. Biol. (2004)
Profiling of Generic Anti-Phosphopeptide Antibodies and Kinases with Peptide Microarrays Using Radioactive and Fluorescence-Based Assays
Panse et al., J. Mol. Divers. (2004)
Molecular Basis for the Substrate Specificity of NIMA-Related Kinase-6 (NEK6). Evidence that NEK6 Does Not Phosphorylate the Hydrophobic Motif of Ribosomal S6 Protein Kinase and Serum- and Glucocorticoid-Induced Protein Kinase In Vivo
Lizcano et al., J. Biol. Chem. (2002)
Local Structural Changes Caused by Peptidyl-Prolyl Cis/Trans Isomerization in the Native State of Proteins
Reimer et al., Biophys. Chem. (2002)
Side-Chain Effects on Peptidyl-Prolyl Cis/Trans Isomerisation
Reimer et al., J. Mol. Biol. (1998)
Intramolecular Assistance of Cis/Trans Isomerization of the Histidine-Proline Moiety
Reimer et al., J. Biochemistry (1997)

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Computational Chemistry: Molecular Design and Lead Optimization

Novel Small Molecule Bradykinin B2 Receptor Antagonists
Gibson et al., J. Med. Chem. (2009)
Effect of Thioxopeptide Bonds on Alpha-Helix Structure and Stability
Reiner et al., J. Am. Chem. Soc. (2008)
On the Benefit of Bivalency in Peptide Ligand/Pin1 Interactions
Daum et al., J. Mol. Biol. (2007)
Design and Synthesis of a New Class of Selective Integrin Alpha5beta1 Antagonists
Stragies et al., J. Med. Chem. (2007)
Translating Peptides into Small Molecules
Hummel et al., Mol. Biosyst. (2006)
Nanomolar Inhibitors of the Peptidyl Prolyl Cis/Trans Isomerase Pin1 from Combinatorial Peptide Libraries
Wildemann et al., J. Med. Chem. (2006)
Molecular Basis for the Binding Polyspecificity of an Anti-Cholera Toxin Peptide 3 Monoclonal Antibody
Otte et al., J. Mol. Recognit. (2006)
Combining SPOT Synthesis and Native Peptide Ligation to Create Large Arrays of WW Protein Domains
Toepert et al., Angew. Chem. Int. Ed. Engl. (2003)
Substrate-based design of reversible Pin1 inhibitors
Zhang et al., Biochemistry (2002)
A Complete Substitutional Analysis of VIP for Better Tumor Imaging Properties
Bhargava et al., J. Mol. Recognit. (2002)
Evolutionary Transition Pathways for Changing Peptide Ligand Specificity and Structure
Hoffmüller et al., EMBO J. (2000)
X-ray Structure of the Quinoprotein Ethanol Dehydrogenase from Pseudomonas Aeruginosa: Basis of Substrate Specificity
Keitel et al., J. Mol. Biol. (2000)
Stepwise Transformation of a Cholera Toxin and a p24 (HIV-1) Epitope into D-Peptide Analogs
Kramer et al., J. Protein Eng. (1998)

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